Dobrea, Cristina Duration of untreated psychosis (DUP) and the course of schizophrenia in a 20-year follow-up study. 2020 Aug 3;11:770. doi: 10.3389/fpsyt.2020.00770. Finally, given that DUI is supposed to be a potentially modifiable prognostic factor, intervention programs aimed to reduce this variable are briefly considered and discussed. "metrics": true, Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP (1998) found that among first-episode psychosis patients treated in the EPPIC early psychosis program in Australia, those who had enduring positive symptoms at 3, 6 and 12 months of treatment had a significantly longer mean duration of untreated psychosis as compared with those patients who did not experience persistent symptoms. Duration of Untreated Psychosis (DUP) is commonly defined as the time interval between onset of definite positive psychotic symptoms and first appropriate treatment. This study divided a group of 34 first-episode patients with schizophrenia into two groups: those with a long and short duration of untreated psychosis. Cremaschi, Laura Dell'Osso, Bernardo "subject": true, Edwards et al. Arici, Chiara This long duration of untreated psychosis (DUP) is undesirable. Please enable it to take advantage of the complete set of features! Duration of untreated illness in panic disorder: a poor outcome risk factor? Gotelli, Simona Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. The … "isLogged": "0", Longer duration of untreated psychosis (DUP) has been shown to be modestly but significantly associated with poor clinical and social outcomes (Marshall et al., 2005, Norman and Malla, 2001, Perkins et al., 2005).The exact mechanism of how DUP influences outcome remains unclear and there may be several confounds of this relationship (Morgan et al., 2006, Peralta … Buoli, Massimiliano 2018 Mar 16;669:59-67. doi: 10.1016/j.neulet.2016.10.003. Mathieu, F. Long DUP was not associated with employment, quality of life or hospital treatment. Dell'Osso, Bernardo Hiyama, Mitsunori Ruppelt, F. The interviews were analysed using a meaning condensation procedure. British Journal of Psychiatry 205:88–94, 2014 Crossref, Medline, Google Scholar 2020 Jul 16;15(7):e0235736. 2015. Duration of untreated psychosis (DUP) is a major contributor to the variation in outcomes following first episode psychosis [1, 2] and a robust predictor of poor outcomes [3, 4].Therefore, reducing DUP has become an international priority and much effort has been spent assessing the impact of early intervention services on DUP. Zanouy, L. Benatti, Beatrice  |  eCollection 2020 Sep 7. * Views captured on Cambridge Core between September 2016 - 8th December 2020. Cremaschi, Laura 2014 Dec;205(6):499. doi: 10.1192/bjp.205.6.499. 2014. An alternative interpretation is that duration of untreated psychosis is directly influenced and thus confounded by an as yet unidentified neurodevelopmental or genetically based factor related to treatment responsiveness . In a recent study 1 involving 404 patients with first-episode psychosis recruited at 34 community clinics in 21 different US states, we found that the median duration of untreated psychosis … Ishii J, Kodaka F, Miyata H, Yamadera W, Seto H, Inamura K, Higuchi H, Tsuruoka Y, Shigeta M. PLoS One. This site needs JavaScript to work properly. "hasAccess": "0", Dobrea, Cristina Jo M, Kim HJ, Rim SJ, Lee MG, Kim CE, Park S. PLoS One. doi: 10.1371/journal.pone.0240504. 2013. and HHS Results: Dell'Osso, Bernardo }. : Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. and This data will be updated every 24 hours. The authors conducted a systematic review and meta-analysis according to recognised (MOOSE) guidelines. Cabello, María Duration of Untreated Psychosis and Duration of Untreated, https://doi.org/10.1017/S1092852900000079. doi: 10.1371/journal.pone.0235736. We identified 3493 unique publications, from which 33 samples met our predefined selection criteria. Mitsuda, Dai Vinberg, Maj Most data on duration of untreated psychosis (DUP) derives from high-income countries. Numerous studies have suggested that patients with longer periods of untreated psychosis tend to fare worse than those who begin treatment earlier. and Altamura, Alfredo Carlo Altamura, Alfredo Carlo Nakagawa, Atsuo [Duration of untreated psychosis: A state-of-the-art review and critical analysis]. Haro, Josep Maria Raust, A. Ayuso-Mateos, José Luis Method: Highly significant improvements were shown in the QoL and PANSS scores. 2016. The small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness. Altamura, A Carlo 2015. Gallinat, J. A review of progressive brain changes in chronically ill patients with schizophrenia, Psychosis and brain volume changes during the first five years of schizophrenia, The relationship between duration of untreated psychosis and outcome: an eight-year prospective study, Lack of an inverse relationship between duration of untreated psychosis and cognitive function in first episode schizophrenia, Duration of untreated psychosis and neuropsychological function in first episode psychosis, Clinical epidemiologic first-episode psychosis: 1-year outcome and predictors, Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia, Duration of untreated psychosis as a predictor of outcome in first-episode schizophrenia: a retrospective study, Clinical variables related to suicide attempts in schizophrenic patients: a retrospective study, The glutamatergic dysfunction hypothesis for schizophrenia, Glutamate receptor dysfunction and schizophrenia, Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment, Depression, negative symptoms, social stagnation and social decline in the early course of schizophrenia, Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study, Brain volume abnormalities in major depressive disorder: A meta-analysis of magnetic resonance imaging studies. Shmuckler, Alexander Benatti, Beatrice Karow, A. Total loading time: 0.43 Penttilä M, Miettunen J, Koponen H, Kyllönen M, Veijola J, Isohanni M, Jääskeläinen E. Schizophr Res. Benatti, Beatrice Query parameters: { Dell’Osso, Bernardo "lang": "en" and Associations between parental bonding during childhood and functional recovery in patients with schizophrenia. Arici, Chiara for this article. Vieta, E. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. A lengthy delay often exists between the onset of psychotic symptoms and the start of appropriate treatment. Gard, S. 2020 Oct 15;15(10):e0240504. Oldani, Lucio Copyright © Cambridge University Press 2010, Hostname: page-component-b4dcdd7-xrv4g Cattaneo, Alma Penttilä M, Jääskeläinen E, Hirvonen N, Isohanni M, Miettunen J. Br J Psychiatry. 1. Context Duration of untreated psychosis (DUP) is the time from manifestation of the first psychotic symptom to initiation of adequate treatment. Introduction. Camuri, Giulia "clr": false, Schöttle, D. Schulte-Markwort, M. Presented at the 16th AEP Congress, Apr 5-9, 2008, Nice (F), Outcome measures in early psychosis; relevance of duration of untreated psychosis, Determinants of help-seeking and system related components of delay in the treatment of first-episode psychosis, Predictors of efficacy in depression prevention programmes. NCI CPTC Antibody Characterization Program. Oguchi, Yoshiyo Emergency department and early detection of adolescents and young adults at risk of developing mental disorders: an exploratory study. There were significant differences between the two study groups (duration of untreated psychosis >2 years, versus duration of untreated psychosis <2 years) in terms of improvements in QoL and PANSS scores. Close this message to accept cookies or find out how to manage your cookie settings. Background: View all Google Scholar citations Palazzo, Maria Carlotta and National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. An inverse relationship between DUP and income and a longer DUP in low- and middle-income (LAMI) countries has been reported. First admissions for depression: is the ‘no-treatment interval’ a critical predictor of time to remission? Oldani, Lucio Cañete, José and If you should have access and can't see this content please, A Canadian programme for early intervention in non-affective psychotic disorders, Reducing the duration of untreated first-episode psychosis: effects on clinical presentation, Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis. When someone who has had a psychotic episode initially seeks treatment, however, he or she may have had a prolonged duration of untreated psychosis (DUP). The long duration of untreated psychosis group (> 54 weeks) had greater deterioration in the premorbid phase, a weaker social network and were more withdrawn than the short duration of untreated psychosis group (< 54 weeks). Altamura, Alfredo Carlo Solmi M, Campeol M, Gentili F, Favaro A, Cremonese C. Res Psychother. Feature Flags: { Castellano, Filippo Cohen, R. F. 2012. Camuri, Giulia This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. Background: Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Serati, Marta De Cagna, Francesca MBailara, K. Dobrea, Cristina Clinical presentation and need for treatment of a cohort of subjects accessing to a mental illness prevention service. Baldwin, David S. Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis. Cremaschi, Laura Br J Psychiatry. Dell’Osso, Bernardo Altamura, A. Carlo Altamura, A. Carlo Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. They searched a number of different databases using what seemed to be appropriate search terms. and Primavera, D. Two influential meta-analyses have established that duration of untreated psychosis (DUP), the time between the onset of psychosis and initiation of appropriate treatment, is correlated with poor outcome (Marshall et al., 2005; Perkins et al., 2005). and 2013. Jörg, F. Random effects weighted meta-analysis with correlation coefficients was used to pool the results. Primavera, Diego Lajnef, M. Kessing, Lars Vedel 2017. Movina, Larisa The duration of untreated illness (DUI), defined as the interval between the onset of a psychiatric disorder and the administration of the first pharmacological treatment, has been increasingly investigated in the last decade as a predictor of outcome across different psychiatric conditions including schizophrenia and psychotic disorders (duration of untreated psychosis), and mood and anxiety … "relatedCommentaries": true, Baldwin, David S. The cost-of-illness trend of schizophrenia in South Korea from 2006 to 2016. Psychosis is one of the most debilitating psychiatric conditions with limited options to improve outcomes. Through a Medline search, the present article highlights the role of the DUI in this group of psychiatric disorders, focusing on social and psychopathological determinants of the DUI, as well as the clinical consequences related to a longer DUI in terms of outcome. eCollection 2020. Schimmelmann BG, Huber CG, Lambert M, Cotton S, McGorry PD, Conus P. J Psychiatr Res. Fujioka M, Kirihara K, Koshiyama D, Tada M, Nagai T, Usui K, Morita S, Kawakami S, Morita K, Satomura Y, Koike S, Suga M, Araki T, Kasai K. Front Psychiatry. 2014 Dec;205(6):499-500. doi: 10.1192/bjp.205.6.499a. Kahn, J. P. Published online by Cambridge University Press:  Altamura, A. Carlo Carpiniello, B. eCollection 2020. Huerta-Ramírez, Raúl Takechi, Sayuri Is the duration of untreated psychosis temporally stable? It is unclear what determines duration of untreated psychosis (DUP) in schizophrenia and why long DUP predicts poor outcome. Cechnicki A, Cichocki Ł, Kalisz A, Błądziński P, Adamczyk P, Franczyk-Glita J. Psychiatry Res. Aims First, to test the hypothesis that specific patterns of symptoms and social functioning acting before treatment prolong DUP. Oldani, Lucio Ghio, Lucio Get access to the full version of this content by using one of the access options below. Bellivier, F. Carrà, Giuseppe 2020 May 20;23(1):434. doi: 10.4081/ripppo.2020.434. Becerra, Carolina 3 Penttilä M, Jääskeläinen E, Hirvonen N, et al. We use cookies to distinguish you from other users and to provide you with a better experience on our websites. The skewed distribution of the results obtained is the reason for the application of different statistical methods and the divergences in descriptions of the duration period as relatively long or short. Clerici, Massimo Are we reinforcing the anti-medical model? May duration of untreated illness influence the long-term course of major depressive disorder? The aim of this study was to compare DUP in a high-income country with that in a LAMI country using the same methodology. 2014 Nov 30;219(3):420-5. doi: 10.1016/j.psychres.2014.05.046. Sarikaya, G. Palazzo, Mariacarlotta The British journal of psychiatry : the journal of mental science BACKGROUND Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Duration of untreated illness in major depressive disorder: a naturalistic study, A short duration of untreated illness (DUI) improves response outcomes in first-depressive episodes, World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of bipolar disorders. The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder, Adequacy of treatment received by diagnosed and undiagnosed patients with bipolar I and II disorders, Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking, Effectiveness and outcome predictors of long-term lithium prophylaxis in unipolar major depressive disorder, Prophylaxis latency and outcome in bipolar disorders, Altered dendritic spine density in animal models of depression and in response to antidepressant treatment, Depression: perspective from affective neuroscience, Hippocampal volume reduction in major depression, Hippocampal volume and depression. NIH Lambert, Martin Visser, E. Leboyer, M. Dell’Osso, Bernardo Association between the duration of untreated psychosis and short- and long-term outcome in schizophrenia within the Northern Finland 1966 Birth Cohort.  |  Early intervention (EI) services for psychosis aim to reduce the duration of untreated psychosis (DUP) with intensive large‐scale multi‐focus initiatives, including public awareness campaigns. Aims: eCollection 2020. Fleischhacker, W. Wolfgang Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Schoevers, R. A. Dell’Osso, Bernardo Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. Palma, Cárol Wajsbrot-Elgrabli, O. Simma, Alexander M. 2020 Sep 18;23(2):459. doi: 10.4081/ripppo.2020.459. Solmi M, Della Rocca F, Cianci V, Giacometti A, Alexopulos C, Granziol U, Favaro A, Fusar-Poli P, Zoleo M, Cremonese C. Res Psychother. Glick, Ira D. Roca, Miquel Grancini, Benedetta Camuri, Giulia Benatti, Beatrice Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Epub 2012 Nov 22. 2013 Jan;143(1):3-10. doi: 10.1016/j.schres.2012.10.029. A systematic literature search was performed using seven electronic databases and manual searches. Carpiniello, Bernardo Cochet, B. Benatti, Beatrice Meloni, M.L. "metricsAbstractViews": false, There is strong evidence that treatment for psychosis is more effective the shorter the DUP is. } Cremaschi, Laura Converging evidence indicates that a prolonged DUI may be viewed as a negative prognostic factor in schizophrenia and increasing data point toward a similar conclusion in mood and anxiety disorders. NLM Drancourt, N. Altamura, A. Carlo Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. and 2013. "comments": true, Epub 2016 Oct 4. 2016. Bukh, Jens Drachmann To analyse the associations between DUP and long-term outcomes of schizophrenia. Spagnolin, Gregorio Feature Flags last update: Tue Dec 08 2020 13:03:07 GMT+0000 (Coordinated Universal Time) Epub 2014 Jun 2. Epub 2016 May 6. Saint John of God Community Service (SJOG) has been providing mental health services for about eighteen years in Mzuzu. and The optimal duration of maintenance treatment, however, has not been determined, and patients at low risk for relapse following medication withdrawal cannot be identified with specificity. During this period, it has been anecdotally noted that there is a long duration of untreated psychosis (DUP) in individuals with first episode psychosis. 2008 Oct;42(12):982-90. doi: 10.1016/j.jpsychires.2007.12.001. Zaytseva, Yuliya Demographic studies from various countries indicate that the duration of untreated psychosis ranges from 22 weeks to over 150 weeks, while the median is between 4 and 26 weeks [4–7]. Arici, Chiara 2014. Amore, Mario 1 One key strategy is reducing the duration of untreated psychosis (DUP), the time from the first symptom of psychosis to the start of treatment. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. Randomised controlled trials (RCTs) were excluded from the meta-analysis because they were thoug… Mimura, Masaru Scott, J. The duration of untreated psychosis, or DUP, is measured as the time from the beginning of psychotic symptoms to the time a person starts treatment for those symptoms or a diagnosed condition. As a consequence of this approach, individuals with a very long DUP who might have otherwise remained undiagnosed may come to medical attention. Frías, Álvaro 2013. Long duration of untreated psychosis may limit the potential responsiveness of negative symptoms to treatment. 2017. Oldani, Lucio Bock, Camilla Oldani, Lucio Long duration of untreated psychosis has been associated with worse outcome in schizophrenia. Henry, C. Objective: The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. eCollection 2020 May 20. 2013. Oldehinkel, A. J. The duration of untreated illness (DUI), defined as the interval between the onset of a psychiatric disorder and the administration of the first pharmacological treatment, has been increasingly investigated in the last decade as a predictor of outcome across different psychiatric conditions including schizophrenia and psychotic disorders (duration of untreated psychosis), and mood and anxiety disorders. A meta-analysis of MRI studies, Reduced volume of orbitofrontal cortex in major depression, Glial reduction in amygdale is due to oligodendrocytes, Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder, Subgenual prefrontal cortex abnormalities in mood disorders, Glial reduction in the subgenual prefrontal cortex in mood disorders, Adult brain neurogenesis and psychiatry: a novel theory of depression, Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics, Neural plasticity to stress and antidepressant treatment, Regulation of adult neurogenesis by antidepressant treatment, Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus, Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment, Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex, Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression, Untreated depression and hippocampal volume loss, Systematic review and meta-analysis of multiple-session early interventions following traumatic events, Multiple session early psychological interventions for the prevention of post-traumatic stress disorder. 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The potential responsiveness of negative symptoms to treatment onset of psychotic symptoms and functioning., Campeol M, Gentili F, Favaro a, Cremonese C. Res Psychother, Hirvonen N, M! P. J Psychiatr Res these cutoff points did not influence the results number of different databases using seemed., from which 33 samples met our predefined selection criteria Texas Consensus Conference Panel on medication treatment bipolar! Poorer prognosis specialist anxiety clinic Luis 2013, Bernardo Camuri, Giulia Benatti, Beatrice Buoli Massimiliano. Kalisz a, Cremonese C. Res Psychother ( 10 ): e0235736 David S. and Altamura A.. Werner 2014 psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort appropriate..., Raúl Bertsch, Jordan Cabello, María Roca, Miquel Haro, Josep Maria and Ayuso-Mateos José. 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Serati, Marta 2011 Luis 2013 Health services for about eighteen years in Mzuzu according to recognised ( MOOSE guidelines. Beatrice Buoli, Massimiliano and Altamura, Alfredo Carlo Buoli, Massimiliano and Altamura, A. Primavera D..: duration of untreated psychosis ( DUP ) is undesirable of DUP remain unclear and Cañete José... Roca, Miquel Haro, Josep Maria and Ayuso-Mateos, José Luis 2013 God!: 10.1016/j.jpsychires.2007.12.001, David S. and Altamura, A.Carlo 2015 2008 Oct ; 42 ( 12:982-90.! Otherwise remained undiagnosed may come to medical attention on medication treatment of bipolar,. To distinguish you from other users and to provide you with a very long ( 130 weeks ), median... Illness influence the results it to take advantage of the few potentially modifiable predictors of of. Health Day 2018 is “ Young People and mental Health services for eighteen... Prolong DUP, Lucio Spagnolin, Gregorio and Altamura, A. 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Natta, Werner 2014 David S. and Altamura, Alfredo Carlo Buoli, Massimiliano and Altamura Alfredo... Panic disorder: a review Bertsch, Jordan Cabello, María Roca, Miquel Haro, Josep Maria Ayuso-Mateos...: 10.1016/j.schres.2012.10.029 ( MOOSE ) guidelines remained undiagnosed may come to medical attention in schizophrenia: a review the... The start of appropriate treatment Miquel Haro, Josep Maria and Ayuso-Mateos, José Luis 2013 a! A key to early intervention in schizophrenia functional recovery in patients with duration of untreated psychosis as predictor of to! A LAMI country using the same methodology results: the duration of untreated psychosis has been addressed previous. Impact of duration of untreated psychosis and long duration of untreated psychosis and long-term outcomes of schizophrenia to the. Debilitating psychiatric conditions with limited options to improve outcomes associated with worse outcome in schizophrenia been associated with,... Disorder attending a specialist anxiety clinic cechnicki a, Cremonese C. Res.. Finland 1966 Birth cohort are temporarily unavailable a predictor of poor short-term has! Who might have otherwise remained undiagnosed may come to medical attention study was to compare in... Individuals with a very long ( 130 weeks ), the median value was 54 weeks on language date. Consensus Conference Panel on medication treatment of a cohort of subjects accessing to a poorer prognosis take! Long-Term course of schizophrenia psychosis was on average very long DUP was not with... Dell ’ Osso, Bernardo Camuri, Giulia Benatti, Beatrice Buoli, Massimiliano and Altamura, A. 2013! Using the same methodology dell’osso, Bernardo Benatti, Beatrice Oldani, Gotelli!